Vanderbilt synergy1/6/2023 ![]() MuS圜 will provide means to perhaps dial down dosages, demising side effects, or even identify unsuspected antagonistic effects.” It is “a small step for a laboratory,” Quaranta continued, but “a big leap for the field of drug combination discovery.” “It is hard to believe, but even some commonly used drug combinations were never measured quantitatively. “The theoretical foundations of MuS圜 immediately pose the question of whether drug combinations that are currently deployed as standard of care should undergo a process of rethinking and retesting within a rigorous framework that quantitatively measures antagonism and synergism,” Quaranta said. “Therefore, I believe understanding this process with rigor will accelerate progress in many areas of biological research.”ĭavid Wooten, PhD’18, and Christian Meyer, PhD’20, who both have backgrounds in physics, imagined the MuS圜 project and, in an initial publication in the journal Cell Systems, explained that MuS圜 has the “potential to transform the enterprise of drug-combination screens.” MuS圜 acts by precisely guiding researchers and physicians to combinations of drugs they can prescribe to patients at lower doses, with improved efficacy, or both. “Drug synergy-or, for that matter, synergy of perturbations to a cell-has been a hotly debated topic for decades,” Lopez said. “The MuS圜 approach opens the way for systematic screening of drug combination, bordering into AI applications when interfaced with databases of chemical compound structures,” said Quaranta, also director of the Quantitative Systems Biology Center. Lopez and Quaranta built reliable synergy metrics and a unique algorithm called MuS圜-named in homage to Vanderbilt’s home in the heart of Music City-to simplify the analysis that determines the efficacy and potency of certain drug combinations against cancer and other diseases. The findings establish a new way to understand, measure and analyze drug synergy and combination. This research led by Vito Quaranta, professor of biochemistry, and Carlos Lopez, associate professor of biochemistry, was published in Nature Communications on July 29. It also develops an open-source analysis tool to help speed such discoveries around the world. Pioneering research from Vanderbilt scientists identifies a measurement system for how well medications work together to help researchers devise new combinations of drugs. The dissertation chronicles the lives of three integral Church Mothers in the COGIC Women's Department, and their roles in shaping the policies and the theology of the denomination and the female members.The Idea Carlos Lopez (Vanderbilt University) Vito Quaranta (Vanderbilt University) ![]() The goal of this work will be to substantiate that although the ordained leadership roles were exclusively male, COGIC Church mothers were and are the teachers, enforcers, modelers and re-definers of Holiness-Pentecostal beliefs in COGIC, through their organization and participation in what is termed the "sanctified life". The Church Mother in COGIC operates parallel to, and in tandem with the exclusively male episcopate. ![]() Within COGIC, the role of Church Mother has been institutionalized, and has been used as an organizational tool to build the denomination, transmit doctrine, and shape behavioral and belief patterns by using a fictive family structure to achieve cohesion throughout the denomination. The office of Church Mother, an unordained leadership role, has extraordinary temporal and spiritual power within the congregation. The Church Mother in the African American religious tradition is an older woman of the congregation, with exemplary spiritual and organizational skills, who acts, as sociologist Cheryl Townsend Gilkes terms " as a counterfoil to the Pastor". ![]() Mason that centers around the Church Mother. COGIC, the largest African American Pentecostal denomination, founded in 1897, has a Women's Department established by denominational head C.H. The dissertation is a history covering the years from 1912-1963 of the Women's Department of the Church of God in Christ (COGIC). ![]()
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